From FFG's Chris:
The Cthulhu genre is among the most recognized and well-regarded in the gaming hobby, and we hope to provide a fast, clever, and horrific collectible card game in this juicy setting, complete with 1920’s paranormal investigations, jaded detectives, mad cultists, and horrors from beyond the stars.
From the press release:
The CALL OF CTHULHU CCG will have no relation or compatibility to the Mythos Collectible Card Game published by Chaosium, Inc in the late 1990’s. Fantasy Flight’s CALL OF CTHULHU CCG will present new and innovative game play which will be simply, fast, and yet provide a deep and dynamic experience for players. The CALL OF CTHULHU CCG will seek to inspire the wonderful flavor of the Cthulhu genre, such as the flavorful "pulp" 1930’s environment, arcane tomes and secrets, paranormal investigations, the elder gods and their terrible servants, dark sinister plots, inhuman conspiracies, and dangers from beyond the stars.
Home Page: http://www.cthulhulcg.com/
Players go head-to-head trying to "complete" three "story cards". Every card in a player's deck may be used as the card itself or used instead as a currency to bring cards out. Characters in the player's tableau may be killed, or driven insane (lose 2 turns). The player decision of using a card for what it can do versus burying the card in order to use it to bring more cards out is the point of tension in the game and really challenges a player's strategy and knowledge of their deck.